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Acknowledgments We would like to thank Professor Jianye Dai (Faculty of Pharmacy, Lanzhou University) and Professor Bin Luo (Faculty of Public Health, Lanzhou University) for help in quality of figures and article structure

Apply an ice pack wrapped in a thin towel for 10-15 minutes at a time

The loss of metabolic homeostasis as we age impedes various functions, leading to a decline in physical abilities

The easily accessible dermis is silently deconstructed by UV rays leading to solar elastosis

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